|Metabolic engineering of bacteria for utilization of mixed sugar substrates for improved production of chemicals and fuel ethanol.
Biofuels 2:303-313. 2011.
T. Jojima, M. Inui and H. Yukawa.
|Heightened concerns about dwindling cheap world oil supplies, and adverse
global climate change blamed on man’s unsustainable dependence on such
finite fossil fuels, have led to increased urgency in the pursuit of new
and effective technologies for the production of energy and chemicals from
renewable feedstocks. Among several viable renewable resources, lignocellulosic
biomass has long been recognized as abundant enough to potentially meet
most future demands for transportation fuels and chemicals. Before this
is realized, however, sizeable advances in technologies that underpin the
concept of the biorefinery must be made. As newer innovations continue
to be made on the way towards industrial-scale lignocellulosic biorefineries,
inefficiencies in the conversion of the pentose sugar component of lignocellulosic
hydrolysates have been so prioritized in numerous experimental biological
production processes as to culminate in a healthy body of literature, particularly
in the last decade or so. This article aims to present the current state
of metabolic engineering of bacteria for utilization of mixed sugar substrates
for improved production of chemicals and fuels from lignocellulosic biomass.