|Cells uptake substrates and convert them into various substances. Such a
process is called "metabolism" and the pathway by which it happens
is termed "metabolic pathway". As shown in the figure, the cellular
metabolic pathway is highly complex and difficult to research even if we
only focus on a particular area of interest. Despite the difficulty,
The cell's metabolic status is a vital information to investigate the production
process. "Metabolome analysis" is a new discipline which provides
such knowledge. In recent years, analytical instruments including LC and
GC have been improved, and new analytical technology and advanced data
analysis capacity lead to the development of highly sensitive GC-MS and
LC-MS/MS. In metabolome analysis, the cells used in the production process
are analyzed at their metabolite level using such advanced instruments.
We are aiming to efficiently obtain superior microorganisms using
the metabolome technology.